Motile and contractile systems
An important area of our research is that of contractile and motile systems. See for example our work published in Science, PNAS, eLife. In particular, we are interested in the recognition and activation of kinesin-1/cargo complexes. My lab has been the first to elucidate the structural basis for the most general mechanism of kinesin-1 recognition as well as an alternative one that is isoform specific.
Mechanistic enzymology
We have a long-standing interest in structural enzymology, particularly of dioxygen-dependent systems. From very old initial work on the flavonol-degrading Aspergillus japonicus quercetinase we have continued our studies on other dioxygen-metabolizing enzymes. Here are some of our papers published in PNAS and Angewandte Chemie Int Ed.
Methods
We have an interest in
crystallographic methods and were involved with the program Refmac5 of the CCP4 suite developed by the Murshudov lab. The collaboration continues to integrate additional experimental techniques within Refmac5.
Over the years our work has been supported by the following funders
© 2021 by Roberto A. Steiner